Micky van de Ven Double Halts The Toffees' Run at New Stadium
The Dutch defender became the initial backline player to score twice in a English top-flight game for Tottenham since Jan Vertonghen in March 2013.
Key points
Micky Van de Ven heads into the net twice in opening period
Everton's defender has goal disallowed after VAR review
Senegalese midfielder scores final goal in 89th minute
This loss is the Merseyside club's initial at Hill Dickinson Stadium
Micky van de Ven found the net twice as Spurs extended their winning streak in away games in the top division and handed the Toffees their first defeat at Hill Dickinson Stadium.
The Toffees were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having departed their historic home behind after 133 years at the end of last season.
But Tottenham's leader Van de Ven pounced on two occasions from set-pieces in the opening 45 minutes to place their impressive record at risk, and they were failed to mount a comeback before Pape Matar Sarr - assisted by ex-Everton forward the Brazilian - headed home a final goal to put the game to bed.
Jake O'Brien thought he had levelled the scores five minutes after the defender's opener, directing a powerful header past Guglielmo Vicario from an set-piece.
The Portuguese striker, meanwhile, failed to convert a number of chances, while Vicario made a series of excellent stops to ensure Tottenham went five matches on the road unbeaten in the English top flight.
But the VAR stepped in, advising Craig Pawson to check the goal on the screen and the official decided that Jack Grealish and Iliman Ndiaye were in an illegal position and had interfered with the Spurs keeper.
The win elevates the manager's side up to third in the Premier League, five points off local foes and table-toppers Arsenal.
The Merseyside club remain in 14th position and are half a dozen points ahead of the relegation zone.
Tottenham analysis: Van de Ven excels in duties at both ends of pitch
Following a uninspiring weekday performance in the Champions League against the French side, where they managed a only two shots on goal, Frank chose Randal Kolo Muani up front instead of former Toffees player the Brazilian.
The new arrival was unable to influence the game before being replaced for Richarlison after 60 minutes on the pitch, but it emerged he proved unnecessary in the end.
Defender the Dutchman converted into an offensive threat to be feared.
Tottenham's opening strike came from a cleverly executed corner routine, with the midfielder directing the ball toward the face of goal for an unmarked Van de Ven to score.
And the captain - stepping up as captain in the Argentine's absence - notched his second in first-half stoppage time as he outjumped the England keeper to head home.
Van de Ven was just as impressive in defensive duties, partnering effectively with his defensive colleague as the duo handled excellently with the 34 crosses sent their way by the opposition.
Toffees breakdown: Everton missing striker's instinct
Everton's recent stadium had been a happy hunting ground, but it appears the novelty may have faded slightly and supporters headed to the exits after Sarr's third for Tottenham.
The break in Everton's winning streak at home will not be a massive concern for David Moyes, but their striker situation are.
The forward and Thierno Barry - the Everton's pair of recognised strikers - had scored just a single goal between them before the weekend's outing.
And they were unable to contribute to that miserable record on a damp and dreary night on in Liverpool.
Beto's performance was summed up when he chose to overhead kick a clear chance from close range, even with having space and time to readjust for a simpler attempt that would have tested Vicario.
Barry, too, failed to influence the game after replacing Beto in the 65th minute.
It wasn't for a shortage of chance. The majority of the home side's attacks came through Grealish and Ndiaye, who tirelessly delivered dangerous balls into the Spurs box.
What next for these two sides?
Everton: The team travel to the Stadium of Light in the top flight on early November at 20:00 GMT.
Tottenham: The London club travel to St James' Park on late October for their next round Carabao Cup tie against the Magpies.